(A generic drug is an exact copy of the active drug in a brand-name medication.). Trelegy Ellipta (generic name: fluticasone furoate/umeclidinium/vilanterol) is a once-daily triple drug inhaler approved for long-term use in asthma or chronic obstructive pulmonary disease (COPD) and must be used daily to be effective. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. Marijuana stays in the system a bit longer, with amounts being detectable for between 1 and 7 days after last use. Instead, youll use a rescue inhaler for sudden trouble breathing. However, no allergic reactions were reported as a side effect of the drug in clinical trials. Once opened, the inhaler is only good for 6 weeks. Spiriva (tiotropium) is a brand-name drug that's used to treat COPD and asthma. You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. Trelegy Ellipta and Breo Ellipta both contain fluticasone furoate and vilanterol. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Trelegy Ellipta. In asthma patients: common cold symptoms (13% to 15%), rhinitis (runny or stuffy nose), painful and frequent urination (signs of a urinary tract infection), upper respiratory tract infection (3% to 6%), bronchitis (3% to 5%), flu, respiratory tract infection, headache (5% to 9%), inflammation of the sinuses, and back pain. your medical condition and treatment and ask if there is any new information about TRELEGY ELLIPTA. Brand-name medications usually cost more than generics. Trelegy Ellipta can interact with several other medications. To prevent yeast infection in your mouth, rinse with water (but do not swallow) after using Trelegy Ellipta. If you have concerns about gaining weight while taking Trelegy Ellipta, talk with your doctor. Trelegy Ellipta has a half-life of between 11 and 24 hours, so it will stay in your bloodstream for up to 5 days after your last dose. Trelegy Ellipta | European Medicines Agency This is because both of these medications have a drug called an anticholinergic in them. These metabolites are either minimally active or have not yet been studied to determine activity. It takes rough 5.5 half-lives for the body to clear most, if not all, of a substance. You can take Trelegy Ellipta in the morning, afternoon or the evening, just be sure to take it at the same time each day. Common medications that may interact with Trelegy Ellipta include: Always tell your doctor and pharmacist about all the medicines you take, including prescription medicines, over-the-counter drugs, vitamins, and herbal dietary supplements. These lists dont include all possible side effects. N Engl J Med. Trelegy Ellipta Inhalation Reviews and User Ratings - WebMD This helps prevent others, including children and pets, from taking the drug by accident. Each person's response to medicine can be different. Adverse Reactions | TRELEGY (fluticasone furoate, umeclidinium Store Trelegy Ellipta at room temperature between 68F to 77F (20C to 25C), away from heat and sunlight. You should use Trelegy Ellipta at the same time each day. * This serious side effect is explained in more detail below in Side effect details.. Trelegy Ellipta: Usage, Side Effects, Warnings - Drugs.com Call your doctor right away if you have serious side effects. However, its possible for the long-term use of inhaled steroids to cause weight gain. Lung function improvements (change from baseline in trough forced expiratory volume over one second [FEV1] at month 12) were also significant in the study. Chronic bronchitis is a. There have been reports of serious allergic reactions, including anaphylaxis, when people with milk allergies take Trelegy Ellipta. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, chronic obstructive pulmonary disease (COPD), forced expiratory volume in 1 second (FEV1), Trelegy Ellipta expiration, storage, and disposal, Professional information for Trelegy Ellipta. If the drug does cause side effects, you may have: A vilanterol overdose may include serious symptoms, such as: Because these medications can affect the heart, your doctor will monitor your heart if you take too much Trelegy Ellipta. Beta-blockers can also increase the risk of bronchospasm (sudden trouble breathing) in people with chronic obstructive pulmonary disease (COPD) or asthma. If youre taking a beta-blocker, tell your doctor before you start using Trelegy Ellipta. Breo comes in a powder. But separate studies have found both Trelegy Ellipta and Symbicort to be effective for treating these conditions. Breo (fluticasone furoate/vilanterol trifenatate), Zara Risoldi Cochrane, Pharm.D., M.S., FASCP, Combivent Respimat (ipratropium/albuterol), COPD lung vs. normal lungs in medical scans, vilanterol, which is a long-acting beta2-agonist (LABA), a bone that breaks more easily than it should, seeing halos or bright colors when looking at lights, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, one strip holds either 100 micrograms (mcg)* or 200 mcg** of fluticasone in each blister, the other strip holds 62.5 mcg of umeclidinium and 25 mcg of vilanterol in each blister, people who took Trelegy Ellipta had 15% fewer flare-ups each year than people who took fluticasone and vilanterol (two of the three drugs in Trelegy Ellipta), people who took Trelegy Ellipta had 25% fewer flare-ups each year than people who took umeclidinium and vilanterol (two of the three drugs in Trelegy Ellipta), 16% of people who took fluticasone and vilanterol, a long-acting beta2-agonist (LABA) and an, asthma symptoms arent well controlled on a long-term asthma medication such as an inhaled corticosteroid ICS), or, asthma is severe enough that it needs to be treated with both an ICS and a long-acting beta2-agonist (LABA) drug. In studies of patients with asthma, a significant improvement in lung function (FEV-1) was seen at 24- and 52-weeks when compared to the use of Breo (fluticasone and vilanterol). Urine tests can detect cannabis in the urine for approximately 3-30 days after use. They may have alternate medications that dont interact with Trelegy Ellipta. There have been reports of very serious allergic reactions in people with milk protein allergies who took other powder medications with lactose in them. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Rates of pneumonia were higher in patients receiving Trelegy triple therapy (8%) compared to Anoro (5%) or Breo (7%) in a 52-week study. The insurance company will review the information and let you and your doctor know if your plan will cover Trelegy Ellipta. If you drink alcohol, talk with your doctor whether its safe for you to continue drinking while youre taking Trelegy Ellipta. If you take umeclidinium with another anticholinergic medication, the drugs effects can combine and increase your risk for side effects. The combination of drugs works to control COPD or asthma symptoms over time. In another clinical study, Trelegy Ellipta was compared with the two active ingredients in Breo Ellipta. Breo Ellipta contains two active drug ingredients: fluticasone and vilanterol. Symbicort has two active drug ingredients in it: budesonide and formoterol. Stimulants including cocaine, meth, and ADHD medications are detectable for about 2 or 3 days. Do not take two doses at one time. It should be stored in a dry place and kept away from sunlight and heat. Trelegy Ellipta also contains umeclidinium. Its not known to interact with supplements or foods. Brand-name medications usually cost more than generics. Trelegy Ellipta was studied in over 10,000 patients with symptomatic chronic obstructive pulmonary disease (COPD) and a history of prior exacerbations (flare-ups). Keep the inhaler dry and away from heat and sunlight. The exact way that fluticasone works to decrease inflammation is not known. Therefore, an overdose isnt likely to occur. In studies, Trelegy has shown a positive effect on breathing tests (FEV1) with the first dose, but it may take several weeks or longer for your overall symptoms to improve in COPD or asthma. Trelegy Ellipta is made of three medications that work to help treat symptoms of asthma. Trelegy Ellipta is also contraindicated in people with allergies to any of the ingredients in the medication, including fluticasone furoate, umeclidinium, vilanterol, lactose monohydrate, and magnesium stearate. Youll take one inhalation (puff) of the medication once a day. Compared to Breo (fluticasone furoate 100 mcg / vilanterol 25 mcg), Trelegy Ellipta 100/62.5/25 mcg once daily showed a 110 mL significant improvement in FEV1 at 24 weeks. mild allergic reaction *. Heres some detail on a few of the side effects this drug may or may not cause. An inactive ingredient is any part of the medication thats not the active ingredient.). Trelegy and Breo are the names of the medications inside the inhalers. If you have a severe protein milk allergy, you shouldnt use Trelegy Ellipta. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Trelegy Ellipta (Fluticasone, Umeclidinium, and Vilanterol) - Inhalation For patients who do not respond adequately to Trelegy Ellipta 100/62.5/25 mcg once daily, increasing the dose to Trelegy Ellipta 200/62.5/25 mcg once daily may provide additional improvement in asthma control. Umeclidinium is minimally orally absorbed. If you have chronic obstructive pulmonary disease (COPD) or asthma, your doctor may suggest treatment with Trelegy Ellipta. A TV commercial promotes Trelegy for COPD. constipation. They can advise you on the best way to feed your child. Trelegy Ellipta costs significantly more than Symbicort. Can diet help improve depression symptoms? Trelegy is the brand name of the medication inside the inhaler. Trelegy is approved as a maintenance (long-term) medicine for use in either chronic obstructive pulmonary disease (COPD) or asthma in adults. This will help to keep you free of symptoms for about 24 hours. It is usually oxidized via hydroxylation or O-dealkylation and then conjugated via glucuronidation to produce metabolites. If you want to find the best Part D plan for you that includes Trelegy, call one of our Licensed Medicare experts at 1-888-376-2028. Fluticasone furoate is an inhaled corticosteroid that works by decreasing inflammation, which is a main component of COPD and asthma symptoms. Trelegy Ellipta is a combination medication. Trelegy Ellipta isnt approved to treat sudden trouble breathing. Compared to Breo (fluticasone furoate / vilanterol) 100/25 mcg, Trelegy Ellipta 100/62.5/25 mcg once daily demonstrated a 110 mL significant improvement in FEV1 over a 24 week period. Trelegy Ellipta interacts with about 500 medications, and most of these interactions are moderate in severity, but may still have an important clinical impact. Improvements in lung function have also been seen when Trelegy was compared to Symbicort Turbuhaler in 24-week studies or with Symbicort plus Spiriva in 12 week studies. Do not use Trelegy Ellipta if you have a severe allergy to milk proteins (like lactose). Trelegy Ellipta has 3 ingredients whose half-lives are between 11 and 24 hours and will stay in your circulation for up to 5 days after the last dose. LAMA and LABA medicines are anticholinergic drugs that help to relax the muscles around the airways in the lungs. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. These lists contain examples of mild side effects that can occur with Trelegy Ellipta, with Symbicort, or with both drugs (when taken individually). Avoid alcohol. Trelegy Ellipta hasnt been studied in pregnant animals either. pain or tenderness around the eyes and cheekbones. There arent any foods that have been specifically reported to interact with Trelegy Ellipta. If you do not have a fast-acting inhaler, call your doctor for a prescription. These lists contain examples of mild side effects that can occur with Trelegy Ellipta, with Breo Ellipta, or with both drugs (when taken individually). Throw away the inhaler 6 weeks after first removing it from the tray or when the dose counter reads zero, whichever comes first. It also helps keep the drug from harming the environment. Trelegy Ellipta is good for only 6 weeks after opening it or until the counter reads 0, meaning that no doses are remaining. A guide to inhaled steroids: Uses, types, and side effects Accessed Oct. 4, 2022 at, Phase III CAPTAIN study of Trelegy Ellipta in patients with asthma meets primary endpoint. How long do they stay in your system? Researchers measured peoples forced expiratory volume in 1 second (FEV1), which is the amount of air you can force out of your lungs in 1 second. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. What is TRELEGY ELLIPTA used for? Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Is it safe to use Trelegy Ellipta while pregnant or breastfeeding? Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. Trelegy Ellipta and Breo Ellipta are both brand-name drugs. Trelegy Ellipta is approved for both the once-daily treatment of adults with chronic obstructive pulmonary disease (COPD) or asthma. Lungs with COPD may be enlarged, have visible air pockets, or show other signs of damage in comparison to healthy lungs. Examples of tricyclic antidepressants include: If youre taking an antidepressant, talk with your doctor before you start using Trelegy Ellipta. Trelegy Ellipta fluticasone furoate 100 mcg / umeclidinium 62.5 mcg / vilanterol 25 mcg inhalation powder (medicine). As with most drugs, some people can have an allergic reaction after taking Trelegy Ellipta. The FDA website provides several useful tips on medication disposal. How long does Trelegy stay in your system? Combivent Respimat (ipratropium and albuterol) is a prescription drug for chronic obstructive pulmonary disease (COPD). Cardiovascular health: Insomnia linked to greater risk of heart attack. It is safe to drink alcohol in moderation if you have COPD and use Trelegy Ellipta. Taking these medications together may increase your risk for side effects. The word Ellipta refers to the specific type of inhaler that contains the drug. The three active drugs in Trelegy Ellipta are fluticasone, umeclidinium, and vilanterol. Trelegy Ellipta is indicated for use in adults with either chronic obstructive pulmonary disease (COPD) or asthma. They may be able to recommend a different diuretic. However, its possible that alcohol may worsen chronic obstructive pulmonary disease (COPD) or asthma symptoms, which Trelegy Ellipta is used to treat. It is approved by the FDA for three uses: for the long-term maintenance of chronic obstructive pulmonary disease (COPD); for the daily maintenance treatment of airflow obstruction in patients with COPD; and for the maintenance treatment of asthma in adults. Blocking these mediators can also decrease inflammation in the airways. A diuretic (water pill) helps your body get rid of extra water and salt. Instead, to treat a flare-up, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). Heres some information about the forms of each drug and how you take them. For more information about what these drugs do, see the How Trelegy Ellipta works section below. Slide. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. Your doctor knows your medical condition the best and can give you a timeline of your treatment response. In clinical trials, Trelegy Ellipta was effective in treating asthma. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. You shouldnt take Trelegy Ellipta if youre also taking tiotropium (Spiriva). https://www.drugs.com/newdrugs/fda-approves-trelegy-ellipta-fluticasone-furoate-umeclidinium-vilanterol-asthma-5350.html, https://www.gsk.com/en-gb/media/press-releases/phase-iii-captain-study-of-trelegy-ellipta-in-patients-with-asthma-meets-primary-endpoint/, https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Trelegy/pdf/TRELEGY-ELLIPTA-PI-PIL-IFU.PDF. Trelegy Ellipta contains lactose as a major excipient. This may cause the anti-inflammatory effects that are seen with fluticasone treatment. This is compared with 3% to 7%* of people who took only fluticasone and vilanterol (two of the three ingredients in Trelegy Ellipta). The maximum recommended dosage is 1 inhalation of TRELEGY ELLIPTA 200/62.5/25 mcg once daily. In animal studies, umeclidinium was seen in the breast milk of mothers who were given the drug. With asthma, you may have symptoms such as: Its important to note that Trelegy Ellipta is meant to be used over time to control asthma symptoms. Both Trelegy Ellipta and Breo Ellipta are approved for use in adults as long-term treatment of: However, Breo Ellipta is approved as a maintenance treatment for asthma only when: Note: Neither Trelegy Ellipta nor Breo Ellipta is approved to treat sudden trouble breathing. Finally, babies whose mothers were given the combination of fluticasone and vilanterol didnt have an increased risk of birth defects. Some antimicrobial drugs inhibit (block) the activity of CYP3A4, which is an enzyme that breaks down Trelegy Ellipta. Use only your fast-acting inhalation medicine (for example, albuterol) for an attack. Trelegy Ellipta can cause mild or serious side effects. This medication is taken as one inhalation (puff) of Trelegy Ellipta once each day. COPD is a long-term lung disease that includes chronic bronchitis, emphysema, or both. Instead, youll use a rescue inhaler for sudden trouble breathing. Trelegy Ellipta Coupon & Prices - Cost $49 per month - NiceRx Over one year, triple therapy with Trelegy was shown to improve rates of COPD flare-ups, improve lung function (FEV1), quality of life and rates of hospitalizations when compared to dual therapy such as Breo Ellipta (fluticasone and vilanterol) or Anoro Ellipta (umeclidinium and vilanterol). But if your symptoms are severe, call 911 or go to the nearest emergency room right away. Clinical studies with over 2,400 patients evaluated improvement in lung function as measured by the change from baseline in trough forced expiratory volume over one second (FEV1) at 24 weeks of treatment. Trelegy Ellipta and Symbicort are both brand-name drugs. In comparison, back pain only occurred in about 1% to 4%* of people who took only fluticasone and vilanterol (two of the three ingredients in Trelegy Ellipta). You can also ask your pharmacist for information on how to dispose of your medication. stomach flu. Your monthly Trelegy Ellipta cost savings if eligible. How long does Sildenafil stay in your system? All rights reserved. For more information, see the Trelegy Ellipta for asthma section below. Trelegy Ellipta is meant to be used as a long-term treatment. You should use Trelegy Ellipta at the same time each day. For more information about what these drugs do, see the How Trelegy Ellipta works section below. Umeclidinium has a half-life of about 11 hours. For instance: In addition to being FDA-approved to treat asthma, Trelegy Ellipta is also FDA-approved to treat chronic obstructive pulmonary disease (COPD). Use Trelegy Ellipta at the same time each day, and not more than once in a 24-hour period. Then, take your next dose at your usual time. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. This helps to lessen symptoms like wheezing, coughing, chest tightness or shortness of breath, all of which make it hard to breath. And some of these side effects can become serious, such as overheating or hallucinating. Symptoms of thrush include mouth pain or white patches in the mouth. (For more about anticholinergics, see Trelegy Ellipta and other anticholinergic medications right below.). Trelegy Ellipta (Fluticasone furoate 100 or 200 micrograms You may wonder how Trelegy Ellipta compares with other medications that are prescribed for similar uses. This medication is taken as one inhalation. Trelegy Ellipta Side Effects Center - RxList Here are answers to some frequently asked questions about Trelegy Ellipta. Talk to your provider right away if you experience blurry vision, eye discomfort, or other changes in their vision after using Trelegy Ellipta. Revised 5/2022. The official half-life of sildenafil is 3-4 hours after an oral dose in the range of 25mg - 200mg. Trelegy Ellipta contains lactose, which is a type of sugar in milk. Trelegy Ellipta costs significantly more than Breo Ellipta. Note: Neither Trelegy Ellipta nor Symbicort is approved to treat sudden trouble breathing. Keep Trelegy Ellipta in a dry place, away from sunlight and heat. We're talking about chronic bronchitis and emphysema. changes in voice quality, such as hoarseness. The inhaler isnt reusable, and you cant refill it. One study showed that FEV1 in people who took Trelegy Ellipta was 59 mL higher than it was in people who took fluticasone and vilanterol. Trelegy Ellipta is a combination medication thats used to treat asthma. Trelegy side effects and how to avoid them - NiceRx Patients taking Trelegy also reported a significant improvement in their health-related quality of life based on an FDA-recognized questionnaire that measures activities, impact on daily life, and symptoms. If you miss a dose of Trelegy Ellipta, take it as soon as you remember. Trelegy is only inhaled once per day because the medication effect lasts for at least 24 hours. Review the full product information for Trelegy Ellipta here and discuss this information with your doctor or other health care provider. Symbicort comes as a metered dose inhaler. Trelegy Ellipta is approved for use in adults ages 18 years and older. Trelegy Ellipta contains three different drugs (fluticasone, umeclidinium, and vilanterol), so you usually wont need to take another maintenance medication along with it. For more information about Trelegy Elliptas approved uses, see the Trelegy Ellipta for COPD and Trelegy Ellipta for asthma sections below. How long a medication remains good can depend on many factors, including how and where you store the medication. And dont swallow the water that you rinse with. That means with a half-life of 5 days, it will likely take 27.5 days-almost a whole month-for the body to clear this drug. Told me absolutely not to use Spiriva and Symbicort - which have worked well for me. In 2020, the FDA approved a third indication for Trelegy Ellipta for maintenance treatment of asthma in adults. Its available only as a brand-name medication. Trelegy Ellipta is approved in two different strengths for asthma, both given once daily. GlaxoSmithKline. If you have a milk allergy, talk with your doctor about safe treatments for your condition. Trelegy Ellipta (fluticasone furoate) - MedicineNet How Long Do Steroids Stay in Your System? - Verywell Health Trelegy Ellipta is also approved for the once-daily maintenance (long-term) treatment of asthma in adults. How Long Does Tren Stay In Your System? - Tren Cycle GSK Press Release. Trelegy Ellipta (generic name: fluticasone furoate / umeclidinium / vilanterol) is an inhaler for asthma or COPD and must be used daily to be effective. In COPD patients: Upper respiratory tract infection, a runny nose and sore throat, pneumonia, taste disturbances, bronchitis, constipation, thrush (yeast infection) in your mouth and throat, painful and frequent urination (signs of a urinary tract infection), headache, nausea, vomiting, and diarrhea, back pain, mouth and throat pain, joint pain, cough, flu, hoarseness, and inflammation of the sinuses. Trelegy Ellipta is not a rescue medicine for bronchospasm attacks and sudden breathing problems. We simply charge $49 a month per medication to cover the cost of our services. Some drugs can prolong (lengthen) a part of your heart rhythm called the QT interval. Trelegy Ellipta is NOT a fast-acting rescue medicine to be used during a sudden breathing attack in COPD or asthma. Higher FEV1s show better lung function, while lower FEV1s show poorer lung function. Because Trelegy Ellipta can also affect your heart rhythm, you shouldnt take these medications while using Trelegy Ellipta. The expiration date helps guarantee that the medication is effective during this time. You should avoid using these medications for at least 2 weeks before you start Trelegy Ellipta treatment. Other drugs that may prolong your QT interval include: If you take any of these medications or other drugs for your heart rhythm, talk with your doctor before you start Trelegy Ellipta treatment. In addition to being FDA-approved to treat chronic obstructive pulmonary disease (COPD), Trelegy Ellipta is also FDA-approved to treat asthma. If youre pregnant or are planning to become pregnant, talk with your doctor before using Trelegy Ellipta. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Rates of pneumonia were higher in the Trelegy Ellipta group. Certain antidepressant medications can interact with Trelegy Ellipta. Store the inhaler in the unopened tray until youre ready to use it. Trelegy Ellipta is a combination medication that contains three drugs: fluticasone, umeclidinium, and vilanterol. The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. Drink plenty of fluids. loss of appetite. With Trelegy Ellipta, there was a 97 mL improvement vs Breo and 54 mL improvement vs Anoro. Only second day but extremely short of breath. When the higher dose Trelegy Ellipta 200/62.5/25 mcg once daily was compared to Breo 200/25 mcg dual therapy, a significant improvement of 92 mL in trough FEV1 was seen for Trelegy. Seek emergency treatment or call 911 if your breathing problems get worse quickly. Heart failure: Could a low sodium diet sometimes do more harm than good? Trelegy Ellipta: Basics, Side Effects & Reviews - GoodRx Clinical trials have shown that when a LABA is used in combination with an ICS, using the LABA does not increase the risk of asthma-related death and hospitalization. ICS medicines work by decreasing lung inflammation (swelling) that can cause breathing problems. Cyclic AMP causes bronchodilation via relaxation of bronchial muscles. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Keep all medications away from children and pets. Trelegy Ellipta contains three active drug ingredients: fluticasone, umeclidinium, and vilanterol. Common side effects when Trelegy is used for asthma included: common cold symptoms, headache, upper respiratory tract infection, and bronchitis. The half-life of fluticasone furoate is about 24 hours. The studies showed that FEV1 in people who took Trelegy Ellipta was between 122 mL and 124 mL higher than it was in people who took fluticasone and vilanterol. The drug vilanterol may relax the uterus, which can prevent contractions and cause problems during labor and delivery. Trelegy Ellipta shouldnt be used later in pregnancy (at or after 28 weeks) or during labor unless recommended by your doctor. For more information on the possible side effects of Trelegy Ellipta, talk with your doctor or pharmacist. TRELEGY in COPD: data from two 12-week studies and a 52-week long-term study Across two 12-week studies in subjects with COPD, the most commonly reported adverse reactions with 1% incidence and more common than BREO were: Long-term safety data: 52-week study in subjects with COPD Trelegy is used once daily in adults with either asthma or COPD to help breathing symptoms and reduce the number of flare-ups by lowering the swelling in your lungs and relaxing your airways.